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Sorafenib was lowered to 200 mg twice a day in case of severe toxicity (grade three or 4 toxicity based on the NCI-CTCAE v3.0), except for patients with grade three hypertension in whom anti-hypertensive medicine have been introduced according to current tips ( 24 ). what is sorafenib used for
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If toxicity was not thereby resolved, remedy was terminated and in that case, patients had been returned to the initially scheduled dose.
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Sorafenib's approval relies on the outcomes of the randomized DETERMINATION (stuDy of sorafEnib in loCally advanced or metastatIc patientS with radioactive Iodine refractory thyrOid caNcer) trial, an international, multicenter, placebo-managed examine involving 417 sufferers.
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There's nexavar without prescription as to which criteria should be used with the intention to assess tumor response to targeted therapies, comparable to sorafenib forty seven The suitable evaluation of tumor response is vital for ensuring that treatment shouldn't be discontinued prematurely because of a perceived absence of scientific benefit.
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